The first Brother Blood was the high priest of the Baltic country of Zandia who refused to supply recruits for Pope Innocent's Fourth Crusade in 1202. During the ensuing battle, the high priest gained the Cloak of Christ, allegedly worn at the Last Supper, but now corrupted with evil. Wearing the cloak, the priest led his knights to victory. He then bathed in his enemies' blood, which gave him great strength and virtual immortality. The priest declared himself Brother Blood and closed Zandia to all strangers. He ruled for 60 years, fathering a son who killed him at the age of 100. So began the Curse of Blood, whereby each son of Zandia's ruler slew his father, bathed in the Bloodpit, then ruled in his place.
Brother Blood enlist the aid of Villains in order to summon the demon Trigon. Villains must prove their worth and defeat a horde of demons before fighting Raven. Once Raven has been subdued Blood will task Villains with embodying the sins of Greed, Gluttony and Wrath. Blood will be present as Villains battle to corrupt the Titans. After the Titans have been corrupted Raven will free the Titans and imprison Blood. Villains must then free Brother Blood.
Brother Blood must be talked to in the Gotham Wastelands for the Envy daily missions.