A Promethium Lockbox is a rare box item dropped randomly by any enemies or players defeated by the player in any instance once they reach level 10.
With each lockbox made from Depleted Promethium; a metal invented and patented by Steve Dayton of Dayton Industries, the lockbox can only be opened through the use of specialized "keys" that contain a chemical known as Volatile Promethium that can eat through the lock.
Starting April 3rd, 2012, once opened the player will be rewarded with a unique consumable item or armor style piece that can only be found within Lockboxes. Due to the unstable nature of Promethium, the player will have 30 days to open a Lockbox before it degrades beyond use. The box's status can be checked by checking the tooltip on the Lockbox in the inventory.
The following items are not available through Promethium Lockboxes anymore since game update 26.