Reign of Blood is a level 5 villain mission started upon the completion of Trigon's Blood (Villains).
- Find and drain the Ankh of Power within the Sentinel base
- "You just leveled Doctor Fate... he's a Lord of Order, you know! I think we'll be keeping you real busy!" — Calculator
- After defeating many sentinels, you must defeat Doctor Fate. Keep moving when he uses displacement orbs. Stay next to Brother Blood when he is draining Doctor Fate to be healed slightly.