- For the mission for heroes, see Trigon's Blood (Heroes).''
Use the Eye of Sin to raise Wrath Demons.
- Travel to Chinatown Music Festival
- Use Eye of Sin on festival patrons to turn them into demons (0/20)
- Defeat Sentinel Vanguards (0/5)
- Use portals outside the Sentinel Base to summon Demon Allies. Help the demon defeat and feed on Sentinels to assault the base. (0/20)
Upon completion, Reign of Blood in automatically started.
- The final battle against the hordes of Sentinels is relatively difficult. Use up all the portals to summon Wrath Demons before going into combat. Their numbers would soon diminish; retreat and wait for the portals to respawn.